Marc Bitoun Selected Research

Congenital Structural Myopathies (Centronuclear Myopathy)

3/2022	Benefits of therapy by dynamin-2-mutant-specific silencing are maintained with time in a mouse model of dominant centronuclear myopathy.
1/2021	Satellite cells deficiency and defective regeneration in dynamin 2-related centronuclear myopathy.
1/2019	Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle.
1/2019	Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin.
1/2019	Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model.
10/2018	Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy.
1/2018	Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.
12/2017	Impaired excitation-contraction coupling in muscle fibres from the dynamin2R465W mouse model of centronuclear myopathy.
1/2017	Loss of Dynamin 2 GTPase function results in microcytic anaemia.
1/2017	Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.

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Marc Bitoun Research Topics

Disease

24	Congenital Structural Myopathies (Centronuclear Myopathy) 03/2022 - 11/2005
6	Muscular Diseases (Myopathy) 01/2022 - 10/2009
2	Atrophy 01/2017 - 12/2010
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2022
1	Neuromuscular Diseases (Neuromuscular Disease) 11/2022
1	Neoplasms (Cancer) 07/2021
1	Lmna-Related Congenital Muscular Dystrophy 03/2018
1	Hereditary Spastic Paraplegia 01/2017
1	Muscle Weakness 11/2016
1	Muscular Atrophy (Muscle Atrophy) 11/2016
1	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) 01/2015
1	Hepatomegaly 06/2012
1	Hypoglycemia (Reactive Hypoglycemia) 06/2012
1	Body Weight (Weight, Body) 06/2012
1	Peripheral Nervous System Diseases (PNS Diseases) 04/2010
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 04/2010
1	Muscular Dystrophies (Muscular Dystrophy) 04/2010

Drug/Important Bio-Agent (IBA)

17	Dynamin IIIBA 03/2022 - 11/2005
8	Dynamins (Dynamin)IBA 01/2022 - 06/2006
3	Proteins (Proteins, Gene)FDA Link 11/2022 - 11/2005
3	GTP Phosphohydrolases (GTPases)IBA 01/2017 - 10/2009
2	ClathrinIBA 01/2019 - 01/2019
2	Small Interfering RNA (siRNA)IBA 01/2018 - 01/2015
1	DystrophinIBA 11/2022
1	DesminIBA 01/2019
1	Messenger RNA (mRNA)IBA 03/2018
1	CalciumIBA 11/2016
1	Keratin-6 (Keratin 6A)IBA 01/2015
1	amphiphysinIBA 12/2014
1	Liver GlycogenIBA 06/2012
1	DysferlinIBA 12/2010
1	UbiquitinIBA 12/2010
1	Creatine Kinase (Creatine Phosphokinase)IBA 04/2010
1	myotubularinIBA 03/2009
1	Phosphoinositide PhosphatasesIBA 03/2009
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 04/2007

Therapy/Procedure

4	Therapeutics 03/2022 - 01/2015